ABSTRACT

The present study was conducted to evaluate the reno-protective effect of rosemary oil (RO) against paracetamol (PCM) toxicity in rats by monitoring the hematological and biochemical parameters as well as renal oxidative stress parameters. Forty male albino rats were divided equally into 4 groups as follow, negative control group (Cont.), paracetamol-intoxicated group (PCM) (500 mg/kg BW), rosemary oil-treated group (RO) (250 mg/kg BW) and PCM+RO group treated with those previously mentioned doses. Rats were orally treated with their relevant doses daily for 6 weeks. Our result revealed that PCM treatment did not affect the erythrogram parameters meanwhile total leukocytic count was significantly elevated. Moreover, liver enzymes activities, glucose, cholesterol, and triglyceride levels were significantly increased in PCM intoxicated group. Also, PCM toxicity resulted in a significant elevation in the kidney function biomarkers and renal malondialdehyde meanwhile, the renal antioxidant system was significantly reduced  (reduced glutathione, superoxide dismutase, and catalase). The rosemary oil improved the adverse effects induced by PCM on liver and kidney function biomarkers that were confirmed histopathologically. In conclusion, the treatment with natural antioxidants like rosemary oil may have a potential protective role against PCM-induced toxicity.

Keywords:  Hepatorenal damage; Paracetamol; Oxidative stress; Rats; Rosemary oil