Tadalafil shows greater renoprotective role than losartan, grape seed extract and ginko biloba against cisplatin-induced nephrotoxicity in rats


Although cisplatin (Cis) is widely used in the treatment of cancers, clinical use of cisplatin is limited due to its nephrotoxicity. There is no specific treatment for Cis-induced renal dysfunction or injury. The present study was to investigate possible protective effect of Tadalafil (Tad), Losartan (Los), Grape seed (G.S) and Ginko biloba (G.B) on Cis -induced renal damages in rats by evaluating biochemical assay and histophathological examination of kidneys. The biochemical assays included the measurements of creatinine, urea, albumin, total protein (TPs), nitric oxide (NO), lactate dehydrogenase (LDH), malonaldehyde (MDA), reduced glutathione (GSH) in the serum and glutathione peroxidase (GPx), superoxide dismutase (SOD) and catalase (CAT) levels in kidney tissue homogenate. The biochemical assay showed that Tad was the best in reducing the levels of serum creatinine, LDH, MDA, phosphorus, potassium and aldosterone hormone and increasing the levels of GSH in the serum and NO levels in serum and kidney homogenate. In addition, Tad greatly reversed Cis- induced histopathological lesions in the kidneys better than the other treatments.

Key words: Biochemical parameters, cisplatin, histopathology, rats, tadalafil.