ABSTRACT

Diabetes Type 2 is one of the most common diseases all over the world that menaces the economies of all countries, particularly for developing  nations. The use of Sulphonylurea drugs especially gliclazide has been taken into consideration for treating the symptoms of diabetes. So, this study was conducted to investigate the effect of gliclazide on normal and diabetic rats via some hematological parameters and biochemical analysis. The experiment was performed on 80 male albino rats, distributed into 4 experimental groups , with 20 rats per groups. Streptozotocin (STZ) was injected at the dose of 55 mg/kg oncelly, intraperitoneal of 2nd group. The 1st group served as control, the 3rd group received 10mg dose of gliclazide and the 4th group  received 55 mg dose of STZ oncelly with 10mg dose of gliclazide by gavages daily for 4weeks. Diabetic animals exhibited higher  blood glucose levels  with altered  body weight . Liver transaminase enzymes, serum creatinine, urea, insulin  and lipid profile  levels were significantly increased ,while sreum total protine and albumin levels were significantly decreased in diabetic rats . Treatment with gliclazide ameliorated hyperglycemia, hyperlipidemia and kidney function. In addition, gliclazide minimized  the histological alterations in the  Pancrease, Liver and kidney of diabetic rats. In conclusion , this study strongly suggests that gliclazide exerts a protective role against diabetes-induced hepatic disease, renal injury and dyslipidemia , by ameliorating high liver enzymes, oxidative stress and hypercholesterolemia.

Key words: gliclazide; Streptozotocin; Diabetes:, hematological parameters; biochemical analysis; Liver enzymes.